There are two types of ER: rough endoplasmic reticulum and smooth endoplasmic reticulum. The outer (cytosolic) face of the rough endoplasmic reticulum is studded with ribosomes that are the sites of protein synthesis. The rough endoplasmic reticulum is especially prominent in cells such as hepatocytes. The smooth endoplasmic reticulum lacks ribosomes and functions in lipid synthesis but not metabolism, the production of steroid hormones, and detoxification. The smooth ER is especially abundant in mammalian liver and gonad cells.