After Snow White, Kreuk's agent sent an audition tape to screenwriters Alfred Gough and Miles Millar, who at the time were putting together the cast of a show they had created for the WB Network entitled Smallville. The series, which was slated to be shot in Vancouver, revolves around the life of teenager Clark Kent before he becomes Superman. Gough and Millar called Kreuk to WB's studios in Burbank, California to audition for the role of Clark Kent's first love, Lana Lang, and she was cast in the part. For a while, Kreuk was starring on both Smallville and Edgemont, although her role on Edgemont slightly diminished over time. Edgemont ended its run in 2005. After seven seasons, Kreuk left Smallville in the beginning of 2008, when her character leaves town. She returned as a guest star in the show's 8th season for five episodes to conclude her storyline.