He has enacted lead roles in romances Deewaanapan (2001), Dil Hai Tumhaara (2002), Dil Ka Rishta (2003), Vaada (2005) and I See You (2006), action films Asambhav (2004) and D-Day (2013), thrillers Yakeen (2005) and Roy (2015), socio-political Chakravyuh (2012), crime drama Inkaar (2013) and biopic Daddy (2017). The year 2002 marked a turning point for Rampal when he was cast in Aankhen, proving to be his first commercial success. His other commercially successful films include, Don (2006) Om Shanti Om (2007), Rock On!! (2008), Housefull (2010) and Ra. One (2011).